New user (incident user) designs can avoid prevalence bias by restricting the analysis to persons under observation at the start of the current course of treatment, therefore with the same baseline risk. Evaluating medication effects outside of clinical trials: new-user designs (Am J Epidemiol 2003;158 (9):915–20). In addition to defining new-user designs, the article explains how they can be implemented as case-control studies and describes the logistical and sample size limitations involved.
|10. Specific topics|
|Annex 1.||Guidance on conducting systematic revies and meta-analyses of completed comparative pharmacoepidemiological studies of safety outcomes|